Living to Dream - Reply JAMA Neurology

Read our thoughtful response to the editorial “Should Neurologists Be Concerned With REM Sleep Quantity?” written about our 2020 REM/Mortality study in JAMA Neurology.

Article: https://jamanetwork.com/journals/jamaneurology/article-abstract/2776791

Leary EB, Stone KL, Mignot E., Living to Dream - Reply JAMA Neurol. April 1, 2021. JAMA Neurol. 2021;78(4):495-496. DOI: 10.1001/jamaneurol.2021.0056. PMID: 33646274.

Peer Reviewed ArticlesEileen LearyCV
The Snooze Button (Podcast)
SnoozeButtonPodcastLogoREV.jpg

Had a great discussion with Neil Hedley from the Snooze Button Podcast.

Our conversation started with my research on REM and mortality but we covered a range of topics including wearables, CBD, and best of all -- sleep nerd fights.

Neil’s podcast is an entertaining and educational medium for learning about the science of sleep as he engages with a range of guests in an effort to better understand his own sleep problems.

Link to Podcast: https://thesnoozebutton.com/the-rem-sleep-youre-not-getting-could-be-killing-you

Speaking EngagementsEileen LearyCV
Reduced REM Sleep is Associated with Mortality in Middle Aged and Older Adults
jama-neurology.png

We investigated whether REM sleep is associated with greater risk of mortality in 2 independent cohorts and explored whether another sleep stage could be driving the findings.

This cross-sectional study from 2 independent cohorts found lower amounts of REM sleep were associated with increased risk of all-cause mortality. There was a 13% higher mortality rate over 12.1 years for every 5% reduction in REM sleep in a cohort of 2675 older men, and the finding was replicated in a cohort of 1375 middle-aged men and women followed-up for 20.8 years.

Article: https://jamanetwork.com/journals/jamaneurology/article-abstract/2767713

Leary EB, Watson KT, Ancoli-Israel S, Redline S, Yaffe K, Ravelo LA, Peppard PE, Zou J, Goodman S, Mignot E, Stone KL for the Osteoporotic Fractures in Men (MrOS) Study Research Group. Reduced REM Sleep is Associated with Mortality in Middle Aged and Older Adults. JAMA Neurol. Published online July 6, 2020. DOI:10.1001/jamaneurol.2020.2108. PMID: 32628261.

Peer Reviewed ArticlesEileen LearyCV
Design of a deep learning model for automatic scoring of periodic and non-periodic leg movements during sleep validated against multiple human experts

Carvellia L, Olesen AN, Brink-Kjær A, Leary EB, Peppard PE, Mignot E, Sørensen HBD, Jennum PJ. Design of a deep learning model for automatic scoring of periodic and non-periodic leg movements during sleep validated against multiple human experts. Sleep Medicine, 2020 May: 109-119. DOI: 10.1016/j.sleep.2019.12.032.

Peer Reviewed ArticlesEileen LearyCV
Jazz Pharmaceuticals (Palo Alto, CA)
jazz-pharma-logo.png

Clinical Scientist

Drove the post-approval research strategy for Global Medical Affairs. Responsible for identifying and prioritizing data gaps, designing and implementing real-world evidence research studies, and articulating to matrix teams and senior leadership how findings can be applied to business and medical decisions.

RolesEileen Leary
Validation of Situational Sleepiness Scale (SSS)
Click image to view full-size PDF.

Click image to view full-size PDF.

Validated a novel scale to evaluate both “active” sleepiness and “passive” sleepiness using questions that reflect modern life.

This study compared the Situational Sleepiness Scale (SSS) to the Epworth Sleepiness Scale (ESS), which is the current standard to assess sleepiness. The scores were highly correlated (rs=0.72) in a sample of 22 Stanford Sleep Medicine patients and 34 healthy controls. We believe the SSS is a can provide more nuanced picture regarding patient’s overall sleepiness, especially while driving and should be evaluated in a wider population.

Singh CT, Leary EB, Mignot E, Stone KL. Validation of the Situational Sleepiness Scale (SSS). Sleep 43(suppl_1), April 2020 (Late Breaking Abstracts).

AbstractsEileen LearyCV