Clinical Scientist
Drove the post-approval research strategy for Global Medical Affairs. Responsible for identifying and prioritizing data gaps, designing and implementing real-world evidence research studies, and articulating to matrix teams and senior leadership how findings can be applied to business and medical decisions.
Scientific Advisor
Supported the creation of a holistic sleep solution through an evidence-backed scientific approach.
Proper Labs: https://www.getproper.com
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Validated a novel scale to evaluate both “active” sleepiness and “passive” sleepiness using questions that reflect modern life.
This study compared the Situational Sleepiness Scale (SSS) to the Epworth Sleepiness Scale (ESS), which is the current standard to assess sleepiness. The scores were highly correlated (rs=0.72) in a sample of 22 Stanford Sleep Medicine patients and 34 healthy controls. We believe the SSS is a can provide more nuanced picture regarding patient’s overall sleepiness, especially while driving and should be evaluated in a wider population.
Singh CT, Leary EB, Mignot E, Stone KL. Validation of the Situational Sleepiness Scale (SSS). Sleep 43(suppl_1), April 2020 (Late Breaking Abstracts).
Mini Poster: Click image to view full-size PDF.
In-depth analysis of the relationship between REM and mortality.
Abstract published in SLEEP summarizing the one hundred and two pages painstakingly researched and written for my PhD in Epidemiology and Clinical Research from Stanford University. An exciting story involving multiple cohorts, machine learning, and meta-analysis will keep you on the edge of your seat!
Leary EB, Watson KT, Ancoli-Israel S, Redline S, Yaffe K, Ravelo LA, Peppard PE, Zou J, Goodman S, Mignot E, Stone KL. The Association Between REM Sleep and Mortality in Three Independent Cohorts. Sleep 43(suppl_1) A19, April 2020.
Full Poster : Click image to view full-size PDF.
Thybo J, Olsen AN, Olsen M, Leary E, Arnal P, Sørensen HB, Jennum P, Mignot E, Stone KL. Fully Automatic Detection of Sleep Disordered breathing Events. Sleep 43(suppl_1) A172, April 2020.
Invited Speaker
Delivered presentation on “Association Between Reduced REM Sleep and Mortality”
Invited Speaker
Delivered presentation on “The Science of Sleep”
Leary EB, Watson KT, Ancoli-Israel S, Redline S, Yaffe K, Ravelo LA, Peppard PE, Zou J, Goodman S, Mignot E, Stone KL. The Association Between REM Sleep and Mortality in the MrOS and Wisconsin Sleep Cohorts. Sleep Medicine Journal Supplement Dec 2019, 579-80.
Invited Speaker
Delivered presentation on “Sleep, What Is It Good For?”
Presenter
Oral presentation of original data on “Association Between Reduced REM Sleep and Mortality”
Kim SJ, Kim S, Jeon S, Leary EB, Barwick F, Mignot E. Factors associated with fatigue in patients with insomnia. J Psychiatr Res. 2019 Oct;117:24-30. DOI: 10.1016/j.jpsychires.2019.06.021. Epub 2019 Jun 28. PMID: 31272015
Presenter
PhD Oral Boards presentation: “Sleep and Death: The Association Between REM Sleep and Mortality.”
Leary EB, Seeger-Zybok RK, Mazurek M, Voronoy A, Lawlor B, Stephenson CL, Kushida C, Mignot E. Development of Complex Data Platform for the Stanford Technology Analytics and Genomics in Sleep (STAGES) Study. Sleep 42(suppl_1):A132, April 2019.
Hanif U, Schneider LD, Trap L, Leary EB, Moore H, Guilleminault C, Jennum P, Sorensen HBD, Mignot EJM. Non-invasive machine learning estimation of effort differentiates sleep-disordered breathing pathology. Physiol Meas. 2019 Feb 26;40(2):025008. PMID 30736016.
Stephansen JB, Olesen AN, Olsen M, Ambati A, Leary EB, Moore HE, Carrillo O, Lin L, Han F, Yan H, Sun YL, Dauvilliers Y, Scholz S, Barateau L, Hogl B, Stefani A, Hong SC, Kim TW, Pizza F, Plazzi G, Vandi S, Antelmi, E, Perrin D, Kuna ST, Schweitzer PK, Kushida C, Peppard PE, Sørensen HB, Jennum P., Mignot E. Neural network analysis of sleep stages enables efficient diagnosis of narcolepsy. Nat Commun., 2018 Dec 6;9(1):5229. PMID 30523329.