Effects of continuous positive airway pressure on neurocognitive function in obstructive sleep apnea patients: The Apnea Positive Pressure Long-term Efficacy Study (APPLES)

Kushida CA, Nichols DA, Holmes TH, Quan SF, Walsh JK, Gottlieb DJ, Simon RD Jr, Guilleminault C, White DP, Goodwin JL, Schweitzer PK, Leary EB, Hyde PR, Hirshkowitz M, Green S, McEvoy LK, Chan C, Gevins A, Kay GG, Bloch DA, Crabtree T, Dement WC. Effects of continuous positive airway pressure on neurocognitive function in obstructive sleep apnea patients: The Apnea Positive Pressure Long-term Efficacy Study (APPLES), Sleep. 2012 Dec 1;35(12):1593-602. PMID:21358847.

The Association between Obstructive Sleep Apnea and Neurocognitive Performance—The Apnea Positive Pressure Long-term Efficacy Study (APPLES)

Quan SF, Chan C, Dement WC, Gevins A, Goodwin JL, Gottlieb DJ, Hirshkowitz M, Hyde PR, Kay GG, Leary EB, Nichols DA, Schweitzer PK, Simon RD, Walsh JK, Kushida CA. The Association between Obstructive Sleep Apnea and Neurocognitive Performance—The Apnea Positive Pressure Long-term Efficacy Study (APPLES). Sleep. 2011 Mar 1;34(3):303-314B. PMID: 23204602.

San Francisco VA Medical Center (San Francisco, CA)

Consultant, Clinical Trial Operations

Advised Dr. Thomas Neylan’s research team on deployment of NIMH’s 1-million-dollar Cognitive Behavioral Treatment of Insomnia in Post-Traumatic Stress Disorder Study: a randomized, 2‑arm controlled trial examining whether CBTi improves sleep in PTSD patients.

  • Developed strategy to launch a complex neurocognitive test battery for the clinical trial.

  • Proposed quality control procedures and created training materials to insure the ongoing integrity of the research data.

RolesEileen Leary